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Article|13 Apr 2023|OPEN
BABA-induced pathogen resistance: a multi-omics analysis of the tomato response reveals a hyper-receptive status involving ethylene
Martina Zapletalová1,2 ,† , Corinne Rancurel1 ,† , Benoit Industri1 , Marc Bardin3 , Kevin Le Brigand4 , Philippe Nicot3 , Virginie Magnone4 , Aurélie Seassau1 , Pascal Barbry4 , David Poteˇsil5 , Zbynek Zdráhal5 and Michel Ponchet1 , Jan Lochman,2 ,
1UMR Institut Sophia Agrobiotech INRAE 1355, CNRS 6254, Université Côte d’Azur, 400, Route des Chappes, 06903 Sophia Antipolis, France
2Department of Biochemistry, Faculty of Science, Masaryk University, Kotlárská 2, 61137 Brno, Czech Republic
3Unité 407 Pathologie végétale, INRAE, Domaine Saint-Maurice, 84143 Montfavet cedex, France
4UMR Institut de Pharmacologie Moléculaire et Cellulaire, Université Côte d’Azur, CNRS 7275, 660 Route des Lucioles 06560 Valbonne, France
5Central European Institute of Technology, Masaryk University, Kamenice 5, 625 00 Brno, Czech Republic
*Corresponding author. E-mail:
Both authors contributed equally to the study.

Horticulture Research 10,
Article number: uhad068 (2023)
Views: 139

Received: 08 Dec 2022
Accepted: 05 Apr 2023
Published online: 13 Apr 2023


Prior exposure to microbial-associated molecular patterns or specific chemical compounds can promote plants into a primed state with stronger defence responses. β-aminobutyric acid (BABA) is an endogenous stress metabolite that induces resistance protecting various plants towards diverse stresses. In this study, by integrating BABA-induced changes in selected metabolites with transcriptome and proteome data, we generated a global map of the molecular processes operating in BABA-induced resistance (BABA-IR) in tomato. BABA significantly restricts the growth of the pathogens Oidium neolycopersici and Phytophthora parasitica but not Botrytis cinerea. A cluster analysis of the upregulated processes showed that BABA acts mainly as a stress factor in tomato. The main factor distinguishing BABA-IR from other stress conditions was the extensive induction of signaling and perception machinery playing a key role in effective resistance against pathogens. Interestingly, the signalling processes and immune response activated during BABA-IR in tomato differed from those in Arabidopsis with substantial enrichment of genes associated with jasmonic acid (JA) and ethylene (ET) signalling and no change in Asp levels. Our results revealed key differences between the effect of BABA on tomato and other model plants studied until now. Surprisingly, salicylic acid (SA) is not involved in BABA downstream signalization whereas ET and JA play a crucial role.