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Letter to the Editor|28 Mar 2023|OPEN
Increased artemisinin production by promoting glandular secretory trichome formation and reconstructing the artemisinin biosynthetic pathway in Artemisia annua
Yongpeng Li1,2 , Wei Qin1 , Hang Liu1 , Tiantian Chen1 , Xin Yan1 , Weizhi He1 , Bowen Peng1 , Jin Shao1 , Xueqing Fu1 , Ling Li1 , Xiaolong Hao2 , and Guoyin Kai2 , , Kexuan Tang,1 ,
1Frontiers Science Center for Transformative Molecules, Joint International Research Laboratory of Metabolic & Developmental Sciences, Key Laboratory of Urban Agriculture (South) Ministry of Agriculture, Plant Biotechnology Research Center, Fudan-SJTU-Nottingham Plant Biotechnology R & D Center, School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai 200240, China
2Laboratory of Medicinal Plant Biotechnology, School of Pharmaceutical Sciences, Academy of Chinese Medical Science, Zhejiang Chinese Medical University, Hangzhou 310053, China
*Corresponding author. E-mail:,,

Horticulture Research 10,
Article number: uhad055 (2023)
Views: 185

Received: 05 Jan 2023
Accepted: 24 Mar 2023
Published online: 28 Mar 2023


Dear Editor,

Artemisinin, which has potent antimalarial properties, is a sesquiterpene endoperoxide originally isolated from the traditional Chinese medicinal plant Artemisia annua. However, the artemisinin content in wild-type (WT) A. annua is low (1–10 mg/g dry weight), leading to its erratic supply and price fluctuations [1]. Recent advances in synthetic biology tools have enabled researchers to engineer several species, including Nicotiana benthamiana and Physcomitrella patens to produce artemisinin [23]. In Saccharomyces cerevisiae, only high-yielding production of the precursor of artemisinin, artemisinic acid (AA), has been achieved, while the synthesis of artemisinin still strictly depends on semi-chemical methods [4]. Meanwhile, current artemisinin production using heterologous expression systems is limited and far from meeting global demand, and A. annua remains its primary commercial source [5].