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Article|15 Jun 2019|OPEN
MDR: an integrative DNA N6-methyladenine and N4-methylcytosine modification database for Rosaceae
Zhao-Yu Liu1 , Jian-Feng Xing1,2 , Wei Chen1 , Mei-Wei Luan1 , Rui Xie3 , Jing Huang4 and Shang-Qian Xie1 , , Chuan-Le Xiao,2 ,
1Hainan Key Laboratory for Biology of Tropical Ornamental Plant Germplasm, Institute of Tropical Agriculture and Forestry, Hainan University, 570228 Haikou, China
2State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, 510060 Guangzhou, China
3Inner Mongolia Academy of Agricultural and Animal Husbandry Sciences, 010031 Huhhot, China
4Department of Agronomy, College of Agriculture, Purdue University, West Lafayette, IN 47907, USA
*Corresponding author. E-mail: sqianxie@hainanu.edu.cn,xiaochuanle@126.com

Horticulture Research 6,
Article number: 78 (2019)
doi: https://doi.org/10.1038/s41438-019-0160-4
Views: 948

Received: 01 Jan 2019
Revised: 23 Apr 2019
Accepted: 26 Apr 2019
Published online: 15 Jun 2019

Abstract

Eukaryotic DNA methylation has been receiving increasing attention for its crucial epigenetic regulatory function. The recently developed single-molecule real-time (SMRT) sequencing technology provides an efficient way to detect DNA N6-methyladenine (6mA) and N4-methylcytosine (4mC) modifications at a single-nucleotide resolution. The family Rosaceae contains horticultural plants with a wide range of economic importance. However, little is currently known regarding the genome-wide distribution patterns and functions of 6mA and 4mC modifications in the Rosaceae. In this study, we present an integrated DNA 6mA and 4mC modification database for the Rosaceae (MDR, http://mdr.xieslab.org). MDR, the first repository for displaying and storing DNA 6mA and 4mC methylomes from SMRT sequencing data sets for Rosaceae, includes meta and statistical information, methylation densities, Gene Ontology enrichment analyses, and genome search and browse for methylated sites in NCBI. MDR provides important information regarding DNA 6mA and 4mC methylation and may help users better understand epigenetic modifications in the family Rosaceae.